\n
\n\tAvustralyal\u0131 ara\u015ft\u0131rmac\u0131lar\u0131n kanseri \u00f6nlemek i\u00e7in \u00f6zel olarak geli\u015ftirilen d\u00fcnyan\u0131n ilk a\u015f\u0131s\u0131n\u0131 yaratmas\u0131n\u0131n \u00fczerinden 20 y\u0131l ge\u00e7ti. HPV a\u015f\u0131s\u0131 sayesinde Avustralya, d\u00fcnyada rahim a\u011fz\u0131 kanserini ortadan kald\u0131ran ilk \u00fclkelerden biri olma yolunda ilerliyor.<\/p>\n
\n\t\u015eimdi Avustralyal\u0131 bilim insanlar\u0131n\u0131n \u00f6nc\u00fcl\u00fck etti\u011fi ara\u015ft\u0131rmalar, bu kez cilt kanseri i\u00e7in yeni bir d\u00f6n\u00fcm noktas\u0131na ula\u015ft\u0131.<\/p>\n
\n\t\u0130lk ki\u015fiselle\u015ftirilmi\u015f mRNA kanser a\u015f\u0131s\u0131, faz 3 klinik denemesinde ba\u015far\u0131l\u0131 oldu ve melanomun n\u00fcksetme veya \u00f6l\u00fcme neden olma riskini tek ba\u015f\u0131na standart imm\u00fcnoterapiye k\u0131yasla y\u00fczde 42 oran\u0131nda azaltt\u0131. Sonu\u00e7lar bilim insanlar\u0131n\u0131n bekledi\u011finden bile daha iyi geldi.<\/p>\n
\n\tK\u00fcresel ba\u015f ara\u015ft\u0131rmac\u0131, Avustralya Melanom Enstit\u00fcs\u00fcnden t\u0131bbi onkolog Georgina Long, sonu\u00e7lar\u0131 2026 Avrupa T\u0131bbi Onkoloji Derne\u011fi Kongresi’nde sundu. Sonu\u00e7lar\u0131n New England Journal of Medicine dergisinde yay\u0131mlanmas\u0131 bekleniyor.<\/p>\n
\n\tKanser tedavisinde temel bir de\u011fi\u015fim<\/h2>\n
\n\tLong, bu bulgular\u0131n kansere yakla\u015f\u0131mda temel bir de\u011fi\u015fim oldu\u011funu ve melanomun n\u00fcksetme veya \u00f6l\u00fcm riskini azaltmak i\u00e7in ba\u011f\u0131\u015f\u0131kl\u0131k sistemini daha ki\u015fiselle\u015ftirilmi\u015f bir \u015fekilde kulland\u0131\u011f\u0131n\u0131 s\u00f6yledi. Bunun, kanser ilac\u0131 geli\u015ftirme tarihinde daha \u00f6nce ba\u015far\u0131lamad\u0131\u011f\u0131n\u0131 belirtti.<\/p>\n
\n\tDenemeye dahil olmayan Amerikan Kanser Ara\u015ft\u0131rmalar\u0131 Derne\u011fi se\u00e7ilmi\u015f ba\u015fkan\u0131 t\u0131bbi onkolog Robert Vonderheide, The New York Times’a verdi\u011fi deme\u00e7te, deneme sonu\u00e7lar\u0131n\u0131n en b\u00fcy\u00fck d\u00f6n\u00fcm noktalar\u0131yla ayn\u0131 seviyede oldu\u011funu s\u00f6yledi.<\/p>\n
\n\tModerna ve Merck taraf\u0131ndan geli\u015ftirilen mRNA a\u015f\u0131s\u0131, ameliyattan sonra melanomun geri d\u00f6nmesini durdurmak i\u00e7in tasarland\u0131. Ara\u015ft\u0131rmac\u0131lar \u00f6nce her hastadaki t\u00fcm\u00f6r\u00fc dizili\u015fine ay\u0131r\u0131yor ve ard\u0131ndan bu t\u00fcm\u00f6r\u00fcn parmak izini v\u00fccuttaki di\u011fer sa\u011fl\u0131kl\u0131 h\u00fccrelerden neyin ay\u0131rd\u0131\u011f\u0131n\u0131 buluyor. Bu bilgilere dayanan bir a\u015f\u0131, hastan\u0131n kendi ba\u011f\u0131\u015f\u0131kl\u0131k sistemi i\u00e7in kanserin ki\u015fiselle\u015ftirilmi\u015f bir aran\u0131yor posterini olu\u015fturuyor.<\/p>\n
\n\tLong, bunun mRNA olarak iletildi\u011fini, b\u00f6ylece v\u00fccudun kendi h\u00fccrelerinin posteri ba\u011f\u0131\u015f\u0131kl\u0131k sistemine g\u00f6stererek tam olarak neye dikkat etmesi ve neye sald\u0131rmas\u0131 gerekti\u011fini g\u00f6sterdi\u011fini s\u00f6yledi. \u0130la\u00e7, Keytruda ad\u0131 verilen mevcut bir imm\u00fcnoterapiyle birlikte \u00e7al\u0131\u015f\u0131yor.<\/p>\n
\n\tKanser h\u00fccrelerinin sahte bir dost\u00e7a el s\u0131k\u0131\u015fmayla ba\u011f\u0131\u015f\u0131kl\u0131k sistemini kand\u0131rabildi\u011fini ve b\u00f6ylece ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin kanser h\u00fccresini normal sand\u0131\u011f\u0131n\u0131 a\u00e7\u0131klayan Long, pembrolizumab\u0131n bu el s\u0131k\u0131\u015fmay\u0131 engelleyerek ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerinin kanseri tan\u0131mas\u0131n\u0131 ve ona sald\u0131rmas\u0131n\u0131 sa\u011flad\u0131\u011f\u0131n\u0131 ancak bunun herkes i\u00e7in ayn\u0131 ila\u00e7 oldu\u011funu ifade etti. Pembrolizumab ile birlikte kullan\u0131lacak bir tedaviyi ki\u015fiselle\u015ftirmek sonu\u00e7lar\u0131 iyile\u015ftiriyor.<\/p>\n
\n\tUmut verici sonu\u00e7lar<\/h2>\n
\n\tFaz 3 klinik denemesine d\u00fcnya \u00e7ap\u0131nda 157 merkezden bin 100’den fazla hasta kat\u0131ld\u0131 ve sonu\u00e7lar 2024 y\u0131l\u0131nda yay\u0131mlanan faz 2 denemesindeki etkileyici bulgular\u0131 destekliyor. Tedaviye ba\u015flad\u0131ktan alt\u0131 ay sonra kansersiz kalan hastalar i\u00e7in melanomun n\u00fcksetme veya \u00f6l\u00fcm riskindeki azalma, tek ba\u015f\u0131na pembrolizumaba k\u0131yasla y\u00fczde 58 oldu.<\/p>\n
\n\tmRNA a\u015f\u0131s\u0131 Avustralya veya Amerika Birle\u015fik Devletleri’ndeki hastalar i\u00e7in hen\u00fcz mevcut de\u011fil ancak sonu\u00e7lar d\u00fczenleyici bir inceleme s\u00fcrecine girdi. Bu s\u00fcrecin \u00fclkeye ba\u011fl\u0131 olarak birka\u00e7 y\u0131l s\u00fcrebilece\u011fi belirtiliyor.<\/p>\n
\n\tD\u00fcnyadaki en y\u00fcksek melanom oranlar\u0131ndan birine sahip olan Avustralya’da her alt\u0131 saatte bir ki\u015fi bu kanserden hayat\u0131n\u0131 kaybediyor. Kanserin n\u00fcksetmesini durdurabilecek bir a\u015f\u0131 \u00e7ok say\u0131da hayat kurtarabilir.<\/p>\n
\n\tmRNA teknolojisinden faydalanabilecek tek alan cilt kanseri de\u011fil. Long, melanomda ba\u015far\u0131l\u0131 olan bu kavram kan\u0131t\u0131n\u0131n, kanseri tedavi etme \u015feklimizde temel bir de\u011fi\u015fimin ba\u015flang\u0131c\u0131n\u0131 i\u015faret edebilece\u011fini ve hastalar\u0131n daha uzun s\u00fcre kansersiz kalmas\u0131na yard\u0131mc\u0131 olabilece\u011fini s\u00f6yledi.<\/p>\n
\n\tAvustralya Melanom Enstit\u00fcs\u00fcnden t\u0131bbi onkolog Alex Menzies de bu g\u00f6r\u00fc\u015fe kat\u0131l\u0131yor. Menzies, yak\u0131n gelecek i\u00e7in umutlar\u0131n\u0131n sadece ilerlemi\u015f hastal\u0131\u011f\u0131 olan melanom hastalar\u0131 i\u00e7in de\u011fil, ayn\u0131 zamanda mevcut imm\u00fcnoterapilerin pek etkili olmad\u0131\u011f\u0131 di\u011fer kanser t\u00fcrlerine sahip olanlar i\u00e7in de sonu\u00e7lar\u0131 iyile\u015ftirmesi oldu\u011funu a\u00e7\u0131klad\u0131.<\/p>\n
\n\tBu heyecan verici bir fikir olsa da hen\u00fcz yap\u0131lmas\u0131 gereken \u00e7ok i\u015f var. Son zamanlarda, kolorektal kanser ile ba\u015f ve boyun kanseri i\u00e7in mRNA a\u015f\u0131lar\u0131n\u0131 test eden birka\u00e7 randomize deneme n\u00fcksetmeyi azaltmada ba\u015far\u0131s\u0131z oldu. Bu durum en yeni sonu\u00e7lar\u0131 daha da \u00f6nemli k\u0131l\u0131yor.<\/p>\n
\n\tLong, denemenin bir hastan\u0131n kendi t\u00fcm\u00f6r\u00fcn\u00fcn benzersiz imzas\u0131ndan olu\u015fturulan tedavinin, kontrol noktas\u0131 inhibit\u00f6r\u00fc imm\u00fcnoterapisiyle birlikte \u00e7al\u0131\u015farak ba\u011f\u0131\u015f\u0131kl\u0131k sistemini kalan kanser h\u00fccrelerini bulup yok etmesi i\u00e7in keskinle\u015ftirebilece\u011fini g\u00f6sterdi\u011fini s\u00f6yledi. E-postan\u0131n ileti\u015fim kurma \u015feklimizi d\u00f6n\u00fc\u015ft\u00fcrmesi gibi ki\u015fiselle\u015ftirilmi\u015f neoantijen tedavisinin de kanseri tedavi etme \u015feklimizi d\u00f6n\u00fc\u015ft\u00fcrme potansiyeline sahip oldu\u011funu s\u00f6zlerine ekledi.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"
Avustralyal\u0131 ara\u015ft\u0131rmac\u0131lar\u0131n kanseri \u00f6nlemek i\u00e7in \u00f6zel olarak geli\u015ftirilen d\u00fcnyan\u0131n ilk a\u015f\u0131s\u0131n\u0131 yaratmas\u0131n\u0131n \u00fczerinden 20 y\u0131l ge\u00e7ti. HPV a\u015f\u0131s\u0131 sayesinde Avustralya, d\u00fcnyada rahim a\u011fz\u0131 kanserini ortadan kald\u0131ran ilk \u00fclkelerden biri olma yolunda ilerliyor.
\u015eimdi Avustralyal\u0131 bilim insanlar\u0131n\u0131n \u00f6nc\u00fcl\u00fck etti\u011fi ara\u015ft\u0131rmalar, bu kez cilt kanseri i\u00e7in yeni bir d\u00f6n\u00fcm noktas\u0131na ula\u015ft\u0131.
\u0130lk ki\u015fiselle\u015ftirilmi\u015f mRNA […]<\/p>\n","protected":false},"author":1,"featured_media":48132,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"footnotes":""},"categories":[2],"tags":[],"class_list":["post-48131","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"yoast_head":"\n
D\u00fcnyan\u0131n ilk kanser a\u015f\u0131s\u0131 melanomun n\u00fcksetme veya \u00f6l\u00fcm riskini y\u00fczde 42 azaltt\u0131 - Haber Kuzey<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/haberkuzey.com\/index.php\/2026\/10\/26\/dunyanin-ilk-kanser-asisi-melanomun-nuksetme-veya-olum-riskini-yuzde-42-azaltti\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"D\u00fcnyan\u0131n ilk kanser a\u015f\u0131s\u0131 melanomun n\u00fcksetme veya \u00f6l\u00fcm riskini y\u00fczde 42 azaltt\u0131 - Haber Kuzey\" \/>\n<meta property=\"og:description\" content=\"
Avustralyal\u0131 ara\u015ft\u0131rmac\u0131lar\u0131n kanseri \u00f6nlemek i\u00e7in \u00f6zel olarak geli\u015ftirilen d\u00fcnyan\u0131n ilk a\u015f\u0131s\u0131n\u0131 yaratmas\u0131n\u0131n \u00fczerinden 20 y\u0131l ge\u00e7ti. HPV a\u015f\u0131s\u0131 sayesinde Avustralya, d\u00fcnyada rahim a\u011fz\u0131 kanserini ortadan kald\u0131ran ilk \u00fclkelerden biri olma yolunda ilerliyor.
\u015eimdi Avustralyal\u0131 bilim insanlar\u0131n\u0131n \u00f6nc\u00fcl\u00fck etti\u011fi ara\u015ft\u0131rmalar, bu kez cilt kanseri i\u00e7in yeni bir d\u00f6n\u00fcm noktas\u0131na ula\u015ft\u0131.
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Avustralyal\u0131 ara\u015ft\u0131rmac\u0131lar\u0131n kanseri \u00f6nlemek i\u00e7in \u00f6zel olarak geli\u015ftirilen d\u00fcnyan\u0131n ilk a\u015f\u0131s\u0131n\u0131 yaratmas\u0131n\u0131n \u00fczerinden 20 y\u0131l ge\u00e7ti. HPV a\u015f\u0131s\u0131 sayesinde Avustralya, d\u00fcnyada rahim a\u011fz\u0131 kanserini ortadan kald\u0131ran ilk \u00fclkelerden biri olma yolunda ilerliyor.
\u015eimdi Avustralyal\u0131 bilim insanlar\u0131n\u0131n \u00f6nc\u00fcl\u00fck etti\u011fi ara\u015ft\u0131rmalar, bu kez cilt kanseri i\u00e7in yeni bir d\u00f6n\u00fcm noktas\u0131na ula\u015ft\u0131.
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