{"id":46804,"date":"2026-09-15T18:36:04","date_gmt":"2026-09-15T15:36:04","guid":{"rendered":"https:\/\/haberkuzey.com\/index.php\/2026\/09\/15\/plastiklerin-insulin-duyarliligini-azalttigi-ilk-kez-insanlarda-gosterildi\/"},"modified":"2026-09-15T18:36:04","modified_gmt":"2026-09-15T15:36:04","slug":"plastiklerin-insulin-duyarliligini-azalttigi-ilk-kez-insanlarda-gosterildi","status":"publish","type":"post","link":"https:\/\/haberkuzey.com\/index.php\/2026\/09\/15\/plastiklerin-insulin-duyarliligini-azalttigi-ilk-kez-insanlarda-gosterildi\/","title":{"rendered":"Plastiklerin ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 azaltt\u0131\u011f\u0131 ilk kez insanlarda g\u00f6sterildi"},"content":{"rendered":"
\n


\n\tG\u0131da ve i\u00e7ecek ambalajlar\u0131nda yayg\u0131n olarak kullan\u0131lan end\u00fcstriyel bir kimyasal olan BPA’n\u0131n, v\u00fccuda al\u0131nd\u0131\u011f\u0131nda ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 fark edilmeden etkileyebilece\u011fi ortaya \u00e7\u0131kt\u0131.<\/p>\n


\n\tBisfenol A (BPA), d\u00fcnya genelinde en y\u00fcksek miktarlarda \u00fcretilen kimyasallardan biri.<\/p>\n


\n\t1960’lardan bu yana \u00e7ok say\u0131da plastik ambalaj\u0131n ve bir\u00e7ok g\u0131da ve i\u00e7ecek kutusunun i\u00e7 y\u00fczeyini kaplayan epoksi re\u00e7inelerin \u00fcretiminde kullan\u0131l\u0131yor.<\/p>\n


\n\tBaz\u0131 tahminlere g\u00f6re BPA o kadar yayg\u0131n t\u00fcketiliyor ki, ABD n\u00fcfusunun y\u00fczde 90’\u0131ndan fazlas\u0131n\u0131n idrar\u0131nda bulunuyor.<\/p>\n

[REUTERS]<\/span><\/div>\n


\n\tPeki bu g\u00fcvenli mi?<\/h2>\n


\n\tABD’deki sa\u011fl\u0131k kurallar\u0131 g\u00fcvenli oldu\u011funu s\u00f6ylese de insanlarda yap\u0131lan ilk deneysel \u00e7al\u0131\u015fma, d\u00fc\u015f\u00fck dozlarda bile BPA t\u00fcketiminin k\u0131sa vadede ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 azaltabilece\u011fini ortaya koydu.<\/p>\n


\n\tAra\u015ft\u0131rman\u0131n k\u0131demli yazar\u0131 ve diyabet ara\u015ft\u0131rmac\u0131s\u0131 Todd Hagobian, 2024’te Amerikan Diyabet Derne\u011finin Bilimsel Oturumlar\u0131’nda \u00f6n sonu\u00e7lar\u0131 sunarken “ABD’de diyabet \u00f6nde gelen \u00f6l\u00fcm nedenlerinden biri. Bu nedenle hastal\u0131\u011fa katk\u0131da bulunan en k\u00fc\u00e7\u00fck fakt\u00f6rleri bile anlamak b\u00fcy\u00fck \u00f6nem ta\u015f\u0131yor.” dedi.<\/p>\n


\n\tHagobian, “Paslanmaz \u00e7elik veya cam \u015fi\u015feler ile BPA i\u00e7ermeyen kutular kullanmak gibi BPA maruziyetini azaltman\u0131n diyabet riskini d\u00fc\u015f\u00fcrebilece\u011fini g\u00f6rmek bizi \u015fa\u015f\u0131rtt\u0131.” dedi.<\/p>\n


\n\tBulgular, Journal of Clinical Endocrinology & Metabolism dergisinde yay\u0131mland\u0131.<\/p>\n


\n\tBe\u015f g\u00fcnde y\u00fczde 9 azald\u0131<\/h2>\n


\n\tRandomize, \u00e7ift k\u00f6r bir klinik \u00e7al\u0131\u015fmada 40 gen\u00e7 yeti\u015fkin, ABD \u00c7evre Koruma Ajans\u0131n\u0131n (EPA) ya\u015fam boyu maruziyet i\u00e7in belirledi\u011fi “g\u00fcvenli” dozda BPA’ya veya plaseboya maruz b\u0131rak\u0131ld\u0131.<\/p>\n


\n\tBe\u015f g\u00fcn\u00fcn sonunda BPA grubunda periferik ins\u00fclin duyarl\u0131l\u0131\u011f\u0131 y\u00fczde 9 azal\u0131rken, plasebo grubunda hafif bir art\u0131\u015f g\u00f6r\u00fcld\u00fc.<\/p>\n


\n\t\u00c7ok say\u0131da hayvan ve g\u00f6zlemsel \u00e7al\u0131\u015fma BPA ile metabolik sa\u011fl\u0131k aras\u0131ndaki ili\u015fkiye i\u015faret etmi\u015f olsa da \u015fa\u015f\u0131rt\u0131c\u0131 derecede az say\u0131da ara\u015ft\u0131rma bu ili\u015fkiyi deneysel olarak test etti.<\/p>\n


\n\tCalifornia Polytechnic State University (CPSU) ve Rutgers \u00dcniversitesinden ara\u015ft\u0131rmac\u0131lar, “Bu sonu\u00e7lar, k\u0131sa s\u00fcreli a\u011f\u0131zdan BPA al\u0131m\u0131n\u0131n ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 bozabilece\u011fine ili\u015fkin insanlarda yay\u0131mlanan ilk deneysel kan\u0131t\u0131 sunuyor.” de\u011ferlendirmesinde bulundu.<\/p>\n


\n\tAra\u015ft\u0131rmac\u0131lar, sonu\u00e7lar\u0131n \u00f6nemli klinik ve halk sa\u011fl\u0131\u011f\u0131 etkileri ta\u015f\u0131d\u0131\u011f\u0131n\u0131 ve \u015fu anda “g\u00fcvenli” kabul edilen dozlarda bile BPA maruziyetinin ins\u00fclin direncinin geli\u015fimine katk\u0131da bulunabilece\u011fini belirtti.<\/p>\n


\n\tBulgular\u0131n toplumun geneline ne \u00f6l\u00e7\u00fcde uygulanabilece\u011fini g\u00f6rmek i\u00e7in daha geni\u015f kapsaml\u0131 \u00e7al\u0131\u015fmalara ihtiya\u00e7 var. Ancak k\u0131sa vadede g\u00f6r\u00fclen de\u011fi\u015fiklikler, \u00f6zellikle mevcut verilerle birlikte de\u011ferlendirildi\u011finde endi\u015fe verici.<\/p>\n


\n\tAra\u015ft\u0131rmac\u0131lar, \u00f6nceki epidemiyolojik, hayvan ve insan \u00e7al\u0131\u015fmalar\u0131n\u0131n yan\u0131 s\u0131ra bu bulgular\u0131n, d\u00fczenleyici kurumlar\u0131n BPA i\u00e7in belirlenen referans dozu yeniden de\u011ferlendirmesi gerekti\u011fine ili\u015fkin kan\u0131tlar\u0131 g\u00fc\u00e7lendirdi\u011fini belirtti.<\/p>\n


\n\tG\u00fcvenli kabul edilen doz yeniden de\u011ferlendirilebilir<\/h2>\n


\n\tABD EPA, BPA t\u00fcketimi i\u00e7in ya\u015fam boyu g\u00fcvenli kabul edilen s\u0131n\u0131r\u0131, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131n kilogram\u0131 ba\u015f\u0131na g\u00fcnde 0,05 miligram olarak belirliyor.<\/p>\n


\n\tBu s\u0131n\u0131r\u0131n alt\u0131nda kal\u0131nd\u0131\u011f\u0131nda BPA’n\u0131n kayda de\u011fer bir zarara yol a\u00e7mas\u0131n\u0131n beklenmedi\u011fi belirtiliyor.<\/p>\n


\n\tAncak bu de\u011fer ilk olarak 1988’de belirlendi ve o zamandan bu yana \u00e7ok \u015fey de\u011fi\u015fti.<\/p>\n


\n\tBilim insanlar\u0131, BPA’n\u0131n v\u00fccutta \u00f6strojeni taklit edebildi\u011fini ve bunun potansiyel olarak zararl\u0131 etkileri olabilece\u011fini yakla\u015f\u0131k bir y\u00fczy\u0131ld\u0131r biliyor.<\/p>\n


\n\tAncak 1990’larda yeni bir geli\u015fme ya\u015fand\u0131. Ara\u015ft\u0131rmac\u0131lar, BPA’n\u0131n \u0131s\u0131t\u0131lm\u0131\u015f polikarbonat ambalajlardan yiyecek ve i\u00e7eceklere ge\u00e7ti\u011fini ilk kez fark etti.<\/p>\n


\n\tDaha sonraki \u00e7al\u0131\u015fmalar BPA’n\u0131n insan h\u00fccrelerinde \u00f6strojen benzeri bir etki olu\u015fturabildi\u011fini g\u00f6sterdi.<\/p>\n


\n\t1997’de canl\u0131 hayvanlar \u00fczerinde yap\u0131lan ilk \u00e7al\u0131\u015fma, hamile farelere g\u00fcnl\u00fck d\u00fc\u015f\u00fck dozda BPA verilmesinin erkek yavrularda olumsuz \u00fcreme etkilerine yol a\u00e7t\u0131\u011f\u0131n\u0131 ortaya koydu.<\/p>\n


\n\tO zamandan bu yana ge\u00e7en onlarca y\u0131lda, binlerce hayvan \u00e7al\u0131\u015fmas\u0131 d\u00fc\u015f\u00fck dozlarda BPA’n\u0131n olumsuz etkilerini g\u00f6sterdi.<\/p>\n


\n\tBunun yan\u0131 s\u0131ra insanlarda yap\u0131lan toplum geneli ara\u015ft\u0131rmalar, daha y\u00fcksek BPA maruziyetinin do\u011furganl\u0131k ve \u00fcreme sorunlar\u0131, n\u00f6rogeli\u015fimde de\u011fi\u015fiklikler, kalp ve damar sorunlar\u0131, tip 2 diyabet ve ins\u00fclin direnci gibi \u00e7ok say\u0131da sa\u011fl\u0131k problemiyle ba\u011flant\u0131l\u0131 oldu\u011funu ortaya koydu.<\/p>\n


\n\tBu durum, BPA’n\u0131n s\u00f6z konusu sorunlar\u0131n t\u00fcm\u00fcne mutlaka neden oldu\u011fu anlam\u0131na gelmiyor. Ancak artan endi\u015feler nedeniyle BPA, ABD’de bebek biberonlar\u0131 ve al\u0131\u015ft\u0131rma bardaklar\u0131nda kullan\u0131mdan \u00e7\u0131kar\u0131ld\u0131.<\/p>\n


\n\tBununla birlikte baz\u0131 kan\u0131tlar, sa\u011fl\u0131kl\u0131 yeti\u015fkinlerde bile EPA’n\u0131n \u015fu anda g\u00fcvenli kabul etti\u011fi dozlarda istenmeyen etkilerin ortaya \u00e7\u0131kabilece\u011fine i\u015faret ediyor.<\/p>\n


\n\t\u00d6rne\u011fin 2019’da CPSU’daki ara\u015ft\u0131rmac\u0131lar, \u00fcniversite \u00e7a\u011f\u0131ndaki 11 kat\u0131l\u0131mc\u0131yla randomize bir \u00e7al\u0131\u015fma ger\u00e7ekle\u015ftirdi. Plaseboyla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, a\u011f\u0131zdan al\u0131nan d\u00fc\u015f\u00fck doz BPA’n\u0131n glikoz ve ins\u00fclin d\u00fczeyleri \u00fczerinde anl\u0131k etkilere yol a\u00e7t\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc.<\/p>\n


\n\tAncak bulgular, sorunun ins\u00fclin salg\u0131s\u0131ndan m\u0131 yoksa ins\u00fclin duyarl\u0131l\u0131\u011f\u0131ndan m\u0131 kaynakland\u0131\u011f\u0131n\u0131 ay\u0131rt etmeye izin vermedi.<\/p>\n


\n\tBunun \u00fczerine ara\u015ft\u0131rma ekibi, daha hassas ins\u00fclin \u00f6l\u00e7\u00fcmleri kullanarak 40 sa\u011fl\u0131kl\u0131 gen\u00e7 yeti\u015fkin \u00fczerinde be\u015f g\u00fcn s\u00fcren daha geni\u015f kapsaml\u0131 bir \u00e7al\u0131\u015fma ger\u00e7ekle\u015ftirdi.<\/p>\n


\n\tKat\u0131l\u0131mc\u0131lar\u0131n yar\u0131s\u0131 rastgele g\u00fcnl\u00fck plasebo almak \u00fczere g\u00f6revlendirilirken, di\u011fer yar\u0131s\u0131na EPA’n\u0131n g\u00fcvenli s\u0131n\u0131rlar\u0131 i\u00e7inde kalan d\u00fc\u015f\u00fck dozda BPA verildi. Di\u011fer t\u00fcm kat\u0131l\u0131mc\u0131lar ayn\u0131 beslenme d\u00fczenini uygulad\u0131.<\/p>\n


\n\tBeklendi\u011fi gibi, g\u00fcnl\u00fck BPA dozu alan kat\u0131l\u0131mc\u0131lar\u0131n idrar\u0131ndaki kimyasal\u0131n konsantrasyonu daha y\u00fcksek \u00e7\u0131kt\u0131.<\/p>\n


\n\tBe\u015f g\u00fcn\u00fcn sonunda bu grupta periferik dokulardaki ins\u00fclin duyarl\u0131l\u0131\u011f\u0131nda da belirgin bir azalma g\u00f6r\u00fcld\u00fc.<\/p>\n


\n\t\u0130lgin\u00e7 \u015fekilde, \u00f6strojenin bu azalmay\u0131 a\u00e7\u0131klamas\u0131 olas\u0131 g\u00f6r\u00fcnmedi.<\/p>\n


\n\tAra\u015ft\u0131rmac\u0131lar periferik dokulardaki ve karaci\u011ferdeki ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 tamamen birbirinden ay\u0131ramasa da karaci\u011ferdeki ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 de\u011ferlendirmek i\u00e7in yayg\u0131n olarak kullan\u0131lan bir \u00f6l\u00e7\u00fcmde herhangi bir farkl\u0131l\u0131k bulamad\u0131.<\/p>\n


\n\tEkip, “Bu durum, BPA’n\u0131n iskelet kaslar\u0131nda ins\u00fclin taraf\u0131ndan uyar\u0131lan glikoz metabolizmas\u0131na m\u00fcdahale etmi\u015f olabilece\u011fini g\u00f6steriyor.” de\u011ferlendirmesinde bulundu.<\/p>\n


\n\tDaha \u00f6nce BPA maruziyeti ile ins\u00fclin direnci aras\u0131ndaki ba\u011flant\u0131ya ili\u015fkin kan\u0131tlar b\u00fcy\u00fck \u00f6l\u00e7\u00fcde ili\u015fkilere dayan\u0131yordu. Ancak yeni \u00e7al\u0131\u015fma \u00e7ift k\u00f6r, plasebo kontroll\u00fc ve randomize bir klinik \u00e7al\u0131\u015fma olarak bu ili\u015fkinin olas\u0131 neden-sonu\u00e7 ba\u011flant\u0131s\u0131na daha \u00f6nce hi\u00e7 olmad\u0131\u011f\u0131 kadar yakla\u015f\u0131lmas\u0131n\u0131 sa\u011fl\u0131yor.<\/p>\n


\n\tBununla birlikte \u00e7al\u0131\u015fmaya \u00fcniversite \u00e7a\u011f\u0131ndaki gen\u00e7 yeti\u015fkinlerin kat\u0131lmas\u0131, bulgular\u0131n toplumun tamam\u0131na genellenemeyebilece\u011fi anlam\u0131na geliyor.<\/p>\n


\n\tAra\u015ft\u0131rma ekibi, “BPA’n\u0131n obezitesi veya prediyabeti\/tip 2 diyabeti bulunan ki\u015filerle nas\u0131l etkile\u015fime girdi\u011fi net de\u011fil ve bu konu daha fazla ara\u015ft\u0131r\u0131lmay\u0131 gerektiriyor.” ifadelerini kulland\u0131.<\/p>\n


\n\tOrtaya \u00e7\u0131kan kan\u0131tlar do\u011frultusunda BPA’n\u0131n Avrupa’daki \u00e7o\u011fu g\u0131da ve i\u00e7ecek \u00fcr\u00fcn\u00fcnde kullan\u0131m\u0131na art\u0131k izin verilmiyor.<\/p>\n


\n\tABD’deki d\u00fczenleyici kurumlar ise BPA’y\u0131 on y\u0131l\u0131 a\u015fk\u0131n s\u00fcredir yeniden de\u011ferlendirmedi.<\/p>\n


\n\tBu y\u0131l ABD’li milletvekilleri, BPA’n\u0131n g\u0131da ambalajlar\u0131nda kullan\u0131m\u0131n\u0131 yasaklayacak “G\u0131dalarda Toksik Maddeler Yok Yasas\u0131” adl\u0131 bir yasa tasar\u0131s\u0131 sundu.<\/p>\n


\n\tYasan\u0131n \u00f6nceki versiyonlar\u0131 ise ba\u015far\u0131s\u0131z olmu\u015ftu.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

G\u0131da ve i\u00e7ecek ambalajlar\u0131nda yayg\u0131n olarak kullan\u0131lan end\u00fcstriyel bir kimyasal olan BPA’n\u0131n, v\u00fccuda al\u0131nd\u0131\u011f\u0131nda ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 fark edilmeden etkileyebilece\u011fi ortaya \u00e7\u0131kt\u0131. Bisfenol A (BPA), d\u00fcnya genelinde en y\u00fcksek miktarlarda \u00fcretilen kimyasallardan biri. 1960’lardan bu yana \u00e7ok say\u0131da plastik ambalaj\u0131n ve bir\u00e7ok g\u0131da ve i\u00e7ecek kutusunun i\u00e7 y\u00fczeyini kaplayan epoksi re\u00e7inelerin \u00fcretiminde kullan\u0131l\u0131yor. […]<\/p>\n","protected":false},"author":1,"featured_media":46805,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"footnotes":""},"categories":[2],"tags":[],"class_list":["post-46804","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"yoast_head":"\nPlastiklerin ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 azaltt\u0131\u011f\u0131 ilk kez insanlarda g\u00f6sterildi - Haber Kuzey<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/haberkuzey.com\/index.php\/2026\/09\/15\/plastiklerin-insulin-duyarliligini-azalttigi-ilk-kez-insanlarda-gosterildi\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Plastiklerin ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 azaltt\u0131\u011f\u0131 ilk kez insanlarda g\u00f6sterildi - Haber Kuzey\" \/>\n<meta property=\"og:description\" content=\" G\u0131da ve i\u00e7ecek ambalajlar\u0131nda yayg\u0131n olarak kullan\u0131lan end\u00fcstriyel bir kimyasal olan BPA’n\u0131n, v\u00fccuda al\u0131nd\u0131\u011f\u0131nda ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 fark edilmeden etkileyebilece\u011fi ortaya \u00e7\u0131kt\u0131. Bisfenol A (BPA), d\u00fcnya genelinde en y\u00fcksek miktarlarda \u00fcretilen kimyasallardan biri. 1960’lardan bu yana \u00e7ok say\u0131da plastik ambalaj\u0131n ve bir\u00e7ok g\u0131da ve i\u00e7ecek kutusunun i\u00e7 y\u00fczeyini kaplayan epoksi re\u00e7inelerin \u00fcretiminde kullan\u0131l\u0131yor. 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