\n
\n\tH\u00fccrelerimizin \u00e7o\u011funda bulunan mikroskobik enerji santralleri olan mitokondriler, ya\u015f ilerledik\u00e7e say\u0131ca azal\u0131r, yava\u015flar ve y\u0131pran\u0131r. Mitokondrilerin kapasitesinin d\u00fc\u015fmesi ise beyinden kalbe kadar bir\u00e7ok hastal\u0131\u011f\u0131n ortaya \u00e7\u0131kmas\u0131na katk\u0131da bulunur.<\/p>\n
\n\tBu yeni ara\u015ft\u0131rmada bilim insanlar\u0131, ya\u015flanan h\u00fccreleri genetik m\u00fcdahale veya ila\u00e7 kullanmadan canland\u0131rman\u0131n bir yolunu buldu. Biyomedikal m\u00fchendisi Akhilesh Gaharwar, bu s\u00fcreci “Sa\u011fl\u0131kl\u0131 h\u00fccreleri, yedek bataryalar\u0131n\u0131 zay\u0131f olanlarla payla\u015fmalar\u0131 i\u00e7in e\u011fittik,” \u015feklinde a\u00e7\u0131kl\u0131yor.<\/p>\n
\n\tNanoflower (Nano \u00c7i\u00e7ekler) teknolojisi nedir?<\/h2>\n
\n\tAra\u015ft\u0131rmac\u0131lar, bu s\u00fcreci tetiklemek i\u00e7in “Nanoflower” (Nano \u00c7i\u00e7ekler) ad\u0131 verilen \u00f6zel, \u00e7i\u00e7ek \u015feklindeki par\u00e7ac\u0131klar\u0131 kulland\u0131. Molybdenum dis\u00fclfit bile\u015fi\u011finden yap\u0131lan bu nanoflower’lar, hedef dokulardaki zararl\u0131 oksijen molek\u00fcllerini (reaktif oksijen t\u00fcrlerini) s\u00fcnger gibi emme yetene\u011fine sahip.<\/p>\n
\n\tBu zararl\u0131 oksijen molek\u00fcllerinin ortamdan temizlenmesi, k\u00f6k h\u00fccrelerde mitokondri \u00fcretimini birka\u00e7 kat art\u0131ran genlerin ifadesini tetikliyor.<\/p>\n
\n\tG\u00fc\u00e7 payla\u015f\u0131m\u0131: Hasarl\u0131 h\u00fccreler canlan\u0131yor<\/h2>\n
\n\tK\u00f6k h\u00fccreler do\u011fal olarak mitokondri payla\u015fma yetene\u011fine sahiptir. Ancak nanoflower’lar sayesinde, laboratuvar deneylerinde bu k\u00f6k h\u00fccreler normalden \u00e7ok daha fazla enerji santraline sahip oldu.<\/p>\n
\n\tAra\u015ft\u0131rmac\u0131lar, normalde beklenenden iki kat daha fazla mitokondri payla\u015f\u0131ld\u0131\u011f\u0131n\u0131 bildirdi.<\/p>\n
\n\tKalp kas\u0131nda bulunan d\u00fcz kas h\u00fccrelerinde mitokondri transferi sayesinde canl\u0131l\u0131k \u00fc\u00e7 ila d\u00f6rt kat artt\u0131.<\/p>\n
\n\tZararl\u0131 kemoterapiye maruz kalan kalp h\u00fccrelerinde bile tedavi edilen h\u00fccrelerin hayatta kalma oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015fti.<\/p>\n
\n\tGelece\u011fe y\u00f6nelik b\u00fcy\u00fck umut<\/h2>\n
\n\tBilim insanlar\u0131, bu yakla\u015f\u0131m\u0131n teorik olarak v\u00fccudun herhangi bir yerindeki h\u00fccreleri gen\u00e7le\u015ftirmek i\u00e7in kullan\u0131labilece\u011fini d\u00fc\u015f\u00fcn\u00fcyor: Kalp hastal\u0131klar\u0131 i\u00e7in kalbe yak\u0131n, kas erimesi (musk\u00fcler distrofi) gibi sorunlar i\u00e7in do\u011frudan kaslara enjekte edilebilir.<\/p>\n
\n\tAra\u015ft\u0131rmac\u0131 John Soukar, “Bu, \u00e7ok \u00e7e\u015fitli vakalar i\u00e7in kullan\u0131labilecek olduk\u00e7a umut verici bir yakla\u015f\u0131m ve sadece ba\u015flang\u0131\u00e7,” diyor.<\/p>\n
\n\tAra\u015ft\u0131rmac\u0131lar, \u015fu an erken a\u015famada olduklar\u0131n\u0131 kabul etseler de, bu heyecan verici ad\u0131m\u0131n ya\u015flanan dokular\u0131 kendi biyolojik mekanizmalar\u0131n\u0131 kullanarak “\u015farj etme” potansiyeline sahip oldu\u011funu belirtiyor. E\u011fer bu do\u011fal g\u00fc\u00e7 payla\u015f\u0131m sistemi g\u00fcvenle desteklenebilirse, bir g\u00fcn h\u00fccresel ya\u015flanman\u0131n baz\u0131 etkilerini yava\u015flatmaya ve hatta tersine \u00e7evirmeye yard\u0131mc\u0131 olabilir.<\/p>\n
\n\tAra\u015ft\u0131rma, PNAS dergisinde yay\u0131mland\u0131.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"
H\u00fccrelerimizin \u00e7o\u011funda bulunan mikroskobik enerji santralleri olan mitokondriler, ya\u015f ilerledik\u00e7e say\u0131ca azal\u0131r, yava\u015flar ve y\u0131pran\u0131r. Mitokondrilerin kapasitesinin d\u00fc\u015fmesi ise beyinden kalbe kadar bir\u00e7ok hastal\u0131\u011f\u0131n ortaya \u00e7\u0131kmas\u0131na katk\u0131da bulunur.
Bu yeni ara\u015ft\u0131rmada bilim insanlar\u0131, ya\u015flanan h\u00fccreleri genetik m\u00fcdahale veya ila\u00e7 kullanmadan canland\u0131rman\u0131n bir yolunu buldu. Biyomedikal m\u00fchendisi Akhilesh Gaharwar, bu s\u00fcreci “Sa\u011fl\u0131kl\u0131 h\u00fccreleri, yedek […]<\/p>\n","protected":false},"author":1,"featured_media":32505,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"footnotes":""},"categories":[2],"tags":[],"class_list":["post-32504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"yoast_head":"\n
Bilimsel ara\u015ft\u0131rma: Ya\u015flanan h\u00fccreler yeniden gen\u00e7le\u015ftirilebilir - Haber Kuzey<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/haberkuzey.com\/index.php\/2025\/12\/03\/bilimsel-arastirma-yaslanan-hucreler-yeniden-genclestirilebilir\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bilimsel ara\u015ft\u0131rma: Ya\u015flanan h\u00fccreler yeniden gen\u00e7le\u015ftirilebilir - Haber Kuzey\" \/>\n<meta property=\"og:description\" content=\"
H\u00fccrelerimizin \u00e7o\u011funda bulunan mikroskobik enerji santralleri olan mitokondriler, ya\u015f ilerledik\u00e7e say\u0131ca azal\u0131r, yava\u015flar ve y\u0131pran\u0131r. Mitokondrilerin kapasitesinin d\u00fc\u015fmesi ise beyinden kalbe kadar bir\u00e7ok hastal\u0131\u011f\u0131n ortaya \u00e7\u0131kmas\u0131na katk\u0131da bulunur.
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H\u00fccrelerimizin \u00e7o\u011funda bulunan mikroskobik enerji santralleri olan mitokondriler, ya\u015f ilerledik\u00e7e say\u0131ca azal\u0131r, yava\u015flar ve y\u0131pran\u0131r. Mitokondrilerin kapasitesinin d\u00fc\u015fmesi ise beyinden kalbe kadar bir\u00e7ok hastal\u0131\u011f\u0131n ortaya \u00e7\u0131kmas\u0131na katk\u0131da bulunur.
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