\n
\n\t\u00c7al\u0131\u015fmada odak noktas\u0131, duygu y\u00f6netimi, hat\u0131rlama ve karar vermede kritik rol oynayan amigdala oldu. Ara\u015ft\u0131rmac\u0131lar, burada bulunan belirli n\u00f6ronlarda a\u015f\u0131r\u0131 aktif hale gelen GRIK4 adl\u0131 geni hedef ald\u0131.<\/p>\n
\n\tBu gen a\u015f\u0131r\u0131 ifade edildi\u011finde GluK4 isimli bir proteinin seviyesini y\u00fckseltiyor ve bu da kayg\u0131ya benzer davran\u0131\u015flar\u0131 tetikliyor: a\u00e7\u0131k alanlardan ka\u00e7\u0131nma, sosyalle\u015fmekten \u00e7ekinme, depresif belirtiler ve nesne tan\u0131ma zorlu\u011fu gibi.<\/p>\n
\n\tGen d\u00fczenleme ile kayg\u0131 belirtileri tamamen ortadan kalkt\u0131<\/h2>\n
\n\tBilim insanlar\u0131 GRIK4 geninin fazla kopyalar\u0131n\u0131 kesip \u00e7\u0131karmak i\u00e7in gen d\u00fczenleme teknikleri kulland\u0131. GluK4 proteininin azalt\u0131lmas\u0131 sonucunda, farelerde t\u00fcm kayg\u0131 ve sosyal \u00e7ekilme belirtileri kayboldu.<\/p>\n
\n\tAra\u015ft\u0131rman\u0131n k\u0131demli isimlerinden n\u00f6robilimci \u00c1lvaro Garc\u00eda,
\n\t\u201cBu kadar basit bir ayarlaman\u0131n kayg\u0131 ve sosyal davran\u0131\u015f bozukluklar\u0131n\u0131 tamamen tersine \u00e7evirmesi ger\u00e7ekten dikkat \u00e7ekici,\u201d dedi.<\/p>\n
\n\tAmigdalan\u0131n belirli bir b\u00f6lgesindeki n\u00f6ronlar anahtar rol oynuyor<\/h2>\n
\n\tEkip, kayg\u0131 davran\u0131\u015flar\u0131n\u0131n bazolateral amigdala (BLA) i\u00e7indeki belirli bir n\u00f6ron grubundan kaynakland\u0131\u011f\u0131n\u0131 ortaya koydu. Bu n\u00f6ronlar\u0131n aktivitesi normale d\u00f6nd\u00fcr\u00fcld\u00fc\u011f\u00fcnde, farelerin davran\u0131\u015f\u0131 da tamamen normale d\u00f6nd\u00fc.<\/p>\n
\n\tTedavi edilen fareler nesne tan\u0131ma testlerinde h\u00e2l\u00e2 zorland\u0131; bu durum, anksiyetenin beyinde amigdala d\u0131\u015f\u0131nda da baz\u0131 b\u00f6lgeleri etkiledi\u011fini ve yaln\u0131zca GRIK4\u2019\u00fcn azalt\u0131lmas\u0131yla onlar\u0131n d\u00fczelmedi\u011fini g\u00f6sterdi.<\/p>\n
\n\t\u00c7al\u0131\u015fman\u0131n ortak yazar\u0131 Juan Merma, \u201cAmigdalan\u0131n kayg\u0131da rol oynad\u0131\u011f\u0131n\u0131 zaten biliyorduk, ancak \u015fimdi yaln\u0131zca bu n\u00f6ron grubunun dengesizli\u011fiyle bile patolojik davran\u0131\u015flar\u0131n ortaya \u00e7\u0131kt\u0131\u011f\u0131n\u0131 g\u00f6sterdik\u201d dedi.<\/p>\n
\n\t\u0130nsanlar i\u00e7in yeni tedavilerin kap\u0131s\u0131n\u0131 aralayabilir<\/h2>\n
\n\tAra\u015ft\u0131rmac\u0131lar, genetik olarak de\u011fi\u015ftirilmemi\u015f ve do\u011fal olarak y\u00fcksek kayg\u0131 d\u00fczeyine sahip farelerde de ayn\u0131 y\u00f6ntemi uygulad\u0131 ve ba\u015far\u0131l\u0131 oldu. Bu, tedavinin daha geni\u015f bir uygulama potansiyeline i\u015faret ediyor.<\/p>\n
\n\t\u00c7al\u0131\u015fma hen\u00fcz insanlarda tekrarlanmad\u0131 ancak fareler bu t\u00fcr beyin ara\u015ft\u0131rmalar\u0131 i\u00e7in g\u00fc\u00e7l\u00fc modeller kabul ediliyor. Bu bulgular, gelecekte insan anksiyetesini hedef alan, \u00e7ok daha lokalize ve etkili tedavi y\u00f6ntemlerinin geli\u015ftirilmesine \u00f6nc\u00fcl\u00fck edebilir.<\/p>\n
\n\t\u00c7al\u0131\u015fman\u0131n son yazarlar\u0131ndan Ram\u00f3n Lerma, \u201cBu \u00f6zel n\u00f6ral devreleri hedeflemek duygu durum bozukluklar\u0131n\u0131 tedavi etmek i\u00e7in etkili ve daha hassas bir strateji olabilir\u201d diye konu\u015ftu.<\/p>\n
\n\tAra\u015ft\u0131rma iScience dergisinde yay\u0131mland\u0131.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"
\u00c7al\u0131\u015fmada odak noktas\u0131, duygu y\u00f6netimi, hat\u0131rlama ve karar vermede kritik rol oynayan amigdala oldu. Ara\u015ft\u0131rmac\u0131lar, burada bulunan belirli n\u00f6ronlarda a\u015f\u0131r\u0131 aktif hale gelen GRIK4 adl\u0131 geni hedef ald\u0131.
Bu gen a\u015f\u0131r\u0131 ifade edildi\u011finde GluK4 isimli bir proteinin seviyesini y\u00fckseltiyor ve bu da kayg\u0131ya benzer davran\u0131\u015flar\u0131 tetikliyor: a\u00e7\u0131k alanlardan ka\u00e7\u0131nma, sosyalle\u015fmekten \u00e7ekinme, depresif belirtiler […]<\/p>\n","protected":false},"author":1,"featured_media":31742,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"footnotes":""},"categories":[2],"tags":[],"class_list":["post-31741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"yoast_head":"\n
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Haber Kuzey","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/kaygi-bozuklugu-tarihe-karisabilir-bilim-insanlari-tetikleyen-noronlari-tanimladi\/","og_locale":"tr_TR","og_type":"article","og_title":"Kayg\u0131 bozuklu\u011fu tarihe kar\u0131\u015fabilir: Bilim insanlar\u0131 tetikleyen n\u00f6ronlar\u0131 tan\u0131mlad\u0131 - Haber Kuzey","og_description":"
\u00c7al\u0131\u015fmada odak noktas\u0131, duygu y\u00f6netimi, hat\u0131rlama ve karar vermede kritik rol oynayan amigdala oldu. Ara\u015ft\u0131rmac\u0131lar, burada bulunan belirli n\u00f6ronlarda a\u015f\u0131r\u0131 aktif hale gelen GRIK4 adl\u0131 geni hedef ald\u0131.
Bu gen a\u015f\u0131r\u0131 ifade edildi\u011finde GluK4 isimli bir proteinin seviyesini y\u00fckseltiyor ve bu da kayg\u0131ya benzer davran\u0131\u015flar\u0131 tetikliyor: a\u00e7\u0131k alanlardan ka\u00e7\u0131nma, sosyalle\u015fmekten \u00e7ekinme, depresif belirtiler […]","og_url":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/kaygi-bozuklugu-tarihe-karisabilir-bilim-insanlari-tetikleyen-noronlari-tanimladi\/","og_site_name":"Haber Kuzey","article_published_time":"2025-11-14T12:30:43+00:00","og_image":[{"url":"https:\/\/trthaberstatic.cdn.wp.trt.com.tr\/resimler\/2372000\/kaygi-anksiyete-beyin-getty-2372625.jpg","type":"","width":"","height":""}],"author":"haberkuzey","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"haberkuzey","Tahmini okuma s\u00fcresi":"2 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/kaygi-bozuklugu-tarihe-karisabilir-bilim-insanlari-tetikleyen-noronlari-tanimladi\/#article","isPartOf":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/kaygi-bozuklugu-tarihe-karisabilir-bilim-insanlari-tetikleyen-noronlari-tanimladi\/"},"author":{"name":"haberkuzey","@id":"https:\/\/haberkuzey.com\/#\/schema\/person\/3372109ec735f9333f4fa47ebb9605ca"},"headline":"Kayg\u0131 bozuklu\u011fu tarihe kar\u0131\u015fabilir: Bilim insanlar\u0131 tetikleyen n\u00f6ronlar\u0131 tan\u0131mlad\u0131","datePublished":"2025-11-14T12:30:43+00:00","mainEntityOfPage":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/kaygi-bozuklugu-tarihe-karisabilir-bilim-insanlari-tetikleyen-noronlari-tanimladi\/"},"wordCount":416,"commentCount":0,"image":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/kaygi-bozuklugu-tarihe-karisabilir-bilim-insanlari-tetikleyen-noronlari-tanimladi\/#primaryimage"},"thumbnailUrl":"https:\/\/haberkuzey.com\/wp-content\/uploads\/2025\/11\/kaygi-anksiyete-beyin-getty-2372625.jpg","articleSection":["D\u00fcnya"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/kaygi-bozuklugu-tarihe-karisabilir-bilim-insanlari-tetikleyen-noronlari-tanimladi\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/kaygi-bozuklugu-tarihe-karisabilir-bilim-insanlari-tetikleyen-noronlari-tanimladi\/","url":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/kaygi-bozuklugu-tarihe-karisabilir-bilim-insanlari-tetikleyen-noronlari-tanimladi\/","name":"Kayg\u0131 bozuklu\u011fu tarihe kar\u0131\u015fabilir: Bilim insanlar\u0131 tetikleyen n\u00f6ronlar\u0131 tan\u0131mlad\u0131 - 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