\n
\n\tAra\u015ft\u0131rmaya g\u00f6re v\u00fccut, benzodiazepin benzeri do\u011fal peptitler \u00fcreterek belirli sinir u\u00e7lar\u0131ndaki a\u011fr\u0131 sinyallerini azaltabiliyor.<\/p>\n
\n\tBu peptitler omurilik gangliyonlar\u0131nda ortaya \u00e7\u0131k\u0131yor ve yaln\u0131zca \u00e7evresel sinir sisteminde etkili olduklar\u0131 i\u00e7in uyku hali, bilin\u00e7 bulan\u0131kl\u0131\u011f\u0131 veya ba\u011f\u0131ml\u0131l\u0131k gibi opioidlerde g\u00f6r\u00fclen yan etkilere yol a\u00e7m\u0131yor.<\/p>\n
\n\tA\u011fr\u0131y\u0131 sinirin ba\u015flad\u0131\u011f\u0131 yerde \u201ck\u0131sma\u201d mekanizmas\u0131<\/h2>\n
\n\t\u00c7al\u0131\u015fmay\u0131 y\u00f6neten Leeds \u00dcniversitesi\u2019nden Prof. Nikita Gamper, mevcut a\u011fr\u0131 kesicilerin s\u0131n\u0131rl\u0131l\u0131klar\u0131n\u0131 hat\u0131rlatarak,
\n\t\u201cOpioidler h\u00e2l\u00e2 en g\u00fc\u00e7l\u00fc a\u011fr\u0131 kesiciler ancak ba\u011f\u0131ml\u0131l\u0131k a\u00e7\u0131s\u0131ndan en risklileri. Daha iyisine ihtiya\u00e7 var,\u201d dedi.<\/p>\n
\n\tEkip, sinir h\u00fccreleriyle ba\u011flant\u0131l\u0131 belirli glial h\u00fccrelerin do\u011fal olarak benzodiazepin benzeri bir peptit salg\u0131lad\u0131\u011f\u0131n\u0131 ke\u015ffetti. Bu peptit, a\u011fr\u0131 sinyallerini ta\u015f\u0131yan sinirlerin aktivitesini azaltarak beynin ald\u0131\u011f\u0131 a\u011fr\u0131 miktar\u0131n\u0131 d\u00fc\u015f\u00fcr\u00fcyor.<\/p>\n
\n\tBu s\u00fcrecin merkezi sinir sistemini etkilememesi, yani kan-beyin bariyerini a\u015fmamas\u0131, mekanizmay\u0131 \u00f6zellikle g\u00fcvenli hale getiriyor. B\u00f6ylece v\u00fccut, a\u011fr\u0131y\u0131 bask\u0131layabilirken sedasyon veya ba\u011f\u0131ml\u0131l\u0131k riski olu\u015fturmuyor.<\/p>\n
\n\tKronik a\u011fr\u0131 tedavisinde yeni umut<\/h2>\n
\n\tLeeds\u2019te a\u011fr\u0131 tedavisi uzman\u0131 Dr. Ganesan Baranidharan, bulgular\u0131n \u00f6nemini \u015f\u00f6yle \u00f6zetledi:<\/p>\n
\n\t\u201cKronik a\u011fr\u0131 sa\u011fl\u0131k hizmetlerinin en b\u00fcy\u00fck sorunlar\u0131ndan biri. Uzun s\u00fcreli opioid ve sinir ila\u00e7lar\u0131 ciddi yan etkiler yaratabiliyor. Bu ara\u015ft\u0131rma yeni ve g\u00fcvenli bir tedavi kap\u0131s\u0131 a\u00e7abilir.\u201d<\/p>\n
\n\tD\u00fcnyada her \u00fc\u00e7 ki\u015fiden birinin ya\u015fam\u0131n\u0131 etkileyen kronik a\u011fr\u0131, en s\u0131k doktora ba\u015fvuru nedenleri aras\u0131nda yer al\u0131yor. Buna ra\u011fmen etkili ve yan etkisi d\u00fc\u015f\u00fck tedavi se\u00e7enekleri s\u0131n\u0131rl\u0131.<\/p>\n
\n\tYeni ila\u00e7lara giden yol a\u00e7\u0131l\u0131yor<\/h2>\n
\n\tAra\u015ft\u0131rman\u0131n Journal of Clinical Investigation dergisinde yay\u0131mlanan sonu\u00e7lar\u0131, yaln\u0131zca periferik sinirlere etki eden yeni nesil a\u011fr\u0131 kesicilerin geli\u015ftirilebilece\u011fini g\u00f6steriyor. Bu ila\u00e7lar:<\/p>\n
\n\tBeyne etki etmeyecek<\/p>\n
\n\tBa\u011f\u0131ml\u0131l\u0131k riski ta\u015f\u0131mayacak<\/p>\n
\n\tSedasyona neden olmayacak<\/p>\n
\n\tA\u011fr\u0131y\u0131 kayna\u011f\u0131nda bask\u0131layacak \u015fekilde tasarlanabilecek.<\/p>\n
\n\tProf. Gamper ve ekibi, ke\u015fiflerini ileriye ta\u015f\u0131mak i\u00e7in 3,5 milyon sterlinlik yeni bir fon ald\u0131. Be\u015f y\u0131l s\u00fcrecek yeni projede n\u00f6ropatik a\u011fr\u0131 biyolojik i\u015faretleyicileri incelenecek ve bu do\u011fal peptit mekanizmas\u0131 temel al\u0131narak yeni tedavi y\u00f6ntemleri geli\u015ftirilecek.<\/p>\n
\n\tBilimsel i\u015f birli\u011fi ba\u015far\u0131y\u0131 h\u0131zland\u0131rd\u0131<\/h2>\n
\n\tAra\u015ft\u0131rma, Leeds \u00dcniversitesi, \u00c7in\u2019deki Hebei T\u0131p \u00dcniversitesi ve Cincinnati \u00dcniversitesi\u2019nin ortak \u00e7al\u0131\u015fmas\u0131yla ortaya \u00e7\u0131kt\u0131. Ekipler, daha \u00f6nce ba\u011f\u0131ms\u0131z y\u00fcr\u00fctt\u00fckleri deneylerde benzer sonu\u00e7lara ula\u015ft\u0131klar\u0131n\u0131 fark ederek i\u015fbirli\u011fini g\u00fc\u00e7lendirdi.<\/p>\n
\n\t\u00c7al\u0131\u015fman\u0131n ortak yazar\u0131 Prof. Xiaona Du, \u201cAyn\u0131 sonuca ula\u015ft\u0131\u011f\u0131m\u0131z\u0131 g\u00f6rd\u00fc\u011f\u00fcm\u00fczde bunun pe\u015finden gitmemiz gerekti\u011fini anlad\u0131k\u201d dedi.<\/p>\n
\n\tSonu\u00e7<\/h2>\n
\n\tBu ke\u015fif, v\u00fccudun kendi sinir sisteminde sakl\u0131 olan do\u011fal bir a\u011fr\u0131 kontrol mekanizmas\u0131n\u0131 g\u00fcn y\u00fcz\u00fcne \u00e7\u0131kar\u0131yor. Bulgular do\u011frulan\u0131r ve klinik uygulamalara d\u00f6n\u00fc\u015f\u00fcrse, gelecekte opioidlerin yerini alabilecek g\u00fcvenli ve ba\u011f\u0131ml\u0131l\u0131k yapmayan yeni a\u011fr\u0131 tedavileri geli\u015ftirilebilir.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"
Ara\u015ft\u0131rmaya g\u00f6re v\u00fccut, benzodiazepin benzeri do\u011fal peptitler \u00fcreterek belirli sinir u\u00e7lar\u0131ndaki a\u011fr\u0131 sinyallerini azaltabiliyor.
Bu peptitler omurilik gangliyonlar\u0131nda ortaya \u00e7\u0131k\u0131yor ve yaln\u0131zca \u00e7evresel sinir sisteminde etkili olduklar\u0131 i\u00e7in uyku hali, bilin\u00e7 bulan\u0131kl\u0131\u011f\u0131 veya ba\u011f\u0131ml\u0131l\u0131k gibi opioidlerde g\u00f6r\u00fclen yan etkilere yol a\u00e7m\u0131yor.
A\u011fr\u0131y\u0131 sinirin ba\u015flad\u0131\u011f\u0131 yerde \u201ck\u0131sma\u201d mekanizmas\u0131
\u00c7al\u0131\u015fmay\u0131 y\u00f6neten Leeds \u00dcniversitesi\u2019nden […]<\/p>\n","protected":false},"author":1,"featured_media":31740,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"footnotes":""},"categories":[2],"tags":[],"class_list":["post-31739","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"yoast_head":"\n
Bilim insanlar\u0131 ba\u011f\u0131ml\u0131l\u0131k yapmayan, do\u011fal bir a\u011fr\u0131 kesme mekanizmas\u0131 ke\u015ffetti - Haber Kuzey<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/bilim-insanlari-bagimlilik-yapmayan-dogal-bir-agri-kesme-mekanizmasi-kesfetti\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bilim insanlar\u0131 ba\u011f\u0131ml\u0131l\u0131k yapmayan, do\u011fal bir a\u011fr\u0131 kesme mekanizmas\u0131 ke\u015ffetti - Haber Kuzey\" \/>\n<meta property=\"og:description\" content=\"
Ara\u015ft\u0131rmaya g\u00f6re v\u00fccut, benzodiazepin benzeri do\u011fal peptitler \u00fcreterek belirli sinir u\u00e7lar\u0131ndaki a\u011fr\u0131 sinyallerini azaltabiliyor.
Bu peptitler omurilik gangliyonlar\u0131nda ortaya \u00e7\u0131k\u0131yor ve yaln\u0131zca \u00e7evresel sinir sisteminde etkili olduklar\u0131 i\u00e7in uyku hali, bilin\u00e7 bulan\u0131kl\u0131\u011f\u0131 veya ba\u011f\u0131ml\u0131l\u0131k gibi opioidlerde g\u00f6r\u00fclen yan etkilere yol a\u00e7m\u0131yor.
A\u011fr\u0131y\u0131 sinirin ba\u015flad\u0131\u011f\u0131 yerde \u201ck\u0131sma\u201d mekanizmas\u0131
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Haber Kuzey","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/bilim-insanlari-bagimlilik-yapmayan-dogal-bir-agri-kesme-mekanizmasi-kesfetti\/","og_locale":"tr_TR","og_type":"article","og_title":"Bilim insanlar\u0131 ba\u011f\u0131ml\u0131l\u0131k yapmayan, do\u011fal bir a\u011fr\u0131 kesme mekanizmas\u0131 ke\u015ffetti - Haber Kuzey","og_description":"
Ara\u015ft\u0131rmaya g\u00f6re v\u00fccut, benzodiazepin benzeri do\u011fal peptitler \u00fcreterek belirli sinir u\u00e7lar\u0131ndaki a\u011fr\u0131 sinyallerini azaltabiliyor.
Bu peptitler omurilik gangliyonlar\u0131nda ortaya \u00e7\u0131k\u0131yor ve yaln\u0131zca \u00e7evresel sinir sisteminde etkili olduklar\u0131 i\u00e7in uyku hali, bilin\u00e7 bulan\u0131kl\u0131\u011f\u0131 veya ba\u011f\u0131ml\u0131l\u0131k gibi opioidlerde g\u00f6r\u00fclen yan etkilere yol a\u00e7m\u0131yor.
A\u011fr\u0131y\u0131 sinirin ba\u015flad\u0131\u011f\u0131 yerde \u201ck\u0131sma\u201d mekanizmas\u0131
\u00c7al\u0131\u015fmay\u0131 y\u00f6neten Leeds \u00dcniversitesi\u2019nden […]","og_url":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/bilim-insanlari-bagimlilik-yapmayan-dogal-bir-agri-kesme-mekanizmasi-kesfetti\/","og_site_name":"Haber Kuzey","article_published_time":"2025-11-14T11:29:42+00:00","og_image":[{"url":"https:\/\/trthaberstatic.cdn.wp.trt.com.tr\/resimler\/2298000\/ilac-2298560.jpg","type":"","width":"","height":""}],"author":"haberkuzey","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"haberkuzey","Tahmini okuma s\u00fcresi":"3 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/bilim-insanlari-bagimlilik-yapmayan-dogal-bir-agri-kesme-mekanizmasi-kesfetti\/#article","isPartOf":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/bilim-insanlari-bagimlilik-yapmayan-dogal-bir-agri-kesme-mekanizmasi-kesfetti\/"},"author":{"name":"haberkuzey","@id":"https:\/\/haberkuzey.com\/#\/schema\/person\/3372109ec735f9333f4fa47ebb9605ca"},"headline":"Bilim insanlar\u0131 ba\u011f\u0131ml\u0131l\u0131k yapmayan, do\u011fal bir a\u011fr\u0131 kesme mekanizmas\u0131 ke\u015ffetti","datePublished":"2025-11-14T11:29:42+00:00","mainEntityOfPage":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/bilim-insanlari-bagimlilik-yapmayan-dogal-bir-agri-kesme-mekanizmasi-kesfetti\/"},"wordCount":557,"commentCount":0,"image":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/bilim-insanlari-bagimlilik-yapmayan-dogal-bir-agri-kesme-mekanizmasi-kesfetti\/#primaryimage"},"thumbnailUrl":"https:\/\/haberkuzey.com\/wp-content\/uploads\/2025\/11\/ilac-2298560.jpg","articleSection":["D\u00fcnya"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/bilim-insanlari-bagimlilik-yapmayan-dogal-bir-agri-kesme-mekanizmasi-kesfetti\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/bilim-insanlari-bagimlilik-yapmayan-dogal-bir-agri-kesme-mekanizmasi-kesfetti\/","url":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/14\/bilim-insanlari-bagimlilik-yapmayan-dogal-bir-agri-kesme-mekanizmasi-kesfetti\/","name":"Bilim insanlar\u0131 ba\u011f\u0131ml\u0131l\u0131k yapmayan, do\u011fal bir a\u011fr\u0131 kesme mekanizmas\u0131 ke\u015ffetti - 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