\n
\n\tABD\u2019deki Wisconsin-Madison \u00dcniversitesi\u2019nden bilim insanlar\u0131, uzun s\u00fcredir nedeni bilinmeyen \u00f6l\u00fcmc\u00fcl hastal\u0131klar\u0131n ard\u0131ndaki biyolojik mekanizmay\u0131 \u00e7\u00f6zd\u00fc. Science dergisinde yay\u0131mlanan ara\u015ft\u0131rmaya g\u00f6re \u201cRPA\u201d adl\u0131 bir protein, kromozomlar\u0131n u\u00e7 k\u0131sm\u0131ndaki telomerleri koruyarak genetik istikrar\u0131 sa\u011fl\u0131yor. Bu proteindeki bozukluklar, telomerlerin k\u0131salmas\u0131na yol a\u00e7arak aplastik anemi, miyelodisplastik sendrom ve akut miyeloid l\u00f6semi gibi ciddi hastal\u0131klara neden olabiliyor.<\/p>\n
\n\tTelomerler, DNA\u2019n\u0131n u\u00e7 k\u0131s\u0131mlar\u0131nda yer alan koruyucu kapaklar olarak g\u00f6rev yap\u0131yor. Ya\u015flanma s\u00fcrecinde do\u011fal olarak k\u0131salan bu b\u00f6lgelerin dengesizli\u011fi, erken ya\u015flanma ve h\u00fccresel hasara yol a\u00e7abiliyor. Ara\u015ft\u0131rma ekibi, telomerleri onaran \u201ctelomeraz\u201d enzimini destekleyen proteinleri inceleyerek RPA\u2019n\u0131n bu s\u00fcre\u00e7teki kilit rol\u00fcn\u00fc ortaya \u00e7\u0131kard\u0131.<\/p>\n
\n\tYapay zek\u00e2 tabanl\u0131 AlphaFold<\/em> yaz\u0131l\u0131m\u0131yla yap\u0131lan modellemeler, RPA\u2019n\u0131n telomeraz\u0131 aktive etti\u011fini ve b\u00f6ylece DNA\u2019n\u0131n sa\u011fl\u0131kl\u0131 \u015fekilde korunmas\u0131n\u0131 sa\u011flad\u0131\u011f\u0131n\u0131 g\u00f6sterdi. Laboratuvar testleri de bu bulgular\u0131 do\u011frulad\u0131.<\/p>\n
\n\t\u00c7al\u0131\u015fmay\u0131 y\u00fcr\u00fcten Prof. Ci Ji Lim, \u201cBaz\u0131 hastalarda telomerlerin neden anormal \u015fekilde k\u0131sa oldu\u011funu anlayam\u0131yorduk. \u015eimdi bunun RPA\u2019n\u0131n telomeraz\u0131 uyaramamas\u0131ndan kaynakland\u0131\u011f\u0131n\u0131 biliyoruz,\u201d dedi.<\/p>\n
\n\tAra\u015ft\u0131rmac\u0131lar, d\u00fcnyan\u0131n farkl\u0131 \u00fclkelerinden doktorlar\u0131n hastalar\u0131nda g\u00f6r\u00fclen genetik mutasyonlar\u0131n RPA i\u015flevini etkileyip etkilemedi\u011fini \u00f6\u011frenmek i\u00e7in kendileriyle ileti\u015fime ge\u00e7ti\u011fini aktard\u0131. Prof. Lim, \u201cBu ke\u015fif, hastalara neden hastaland\u0131klar\u0131n\u0131 anlatabilmemiz a\u00e7\u0131s\u0131ndan b\u00fcy\u00fck bir ad\u0131m,\u201d diye konu\u015ftu.<\/p>\n
\n\tBilim insanlar\u0131na g\u00f6re RPA\u2019n\u0131n rol\u00fcn\u00fc anlamak, gelecekte erken tan\u0131 ve ki\u015fiye \u00f6zel tedavi y\u00f6ntemlerinin geli\u015ftirilmesinde de \u00f6nemli bir d\u00f6n\u00fcm noktas\u0131 olacak.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"
ABD\u2019deki Wisconsin-Madison \u00dcniversitesi\u2019nden bilim insanlar\u0131, uzun s\u00fcredir nedeni bilinmeyen \u00f6l\u00fcmc\u00fcl hastal\u0131klar\u0131n ard\u0131ndaki biyolojik mekanizmay\u0131 \u00e7\u00f6zd\u00fc. Science dergisinde yay\u0131mlanan ara\u015ft\u0131rmaya g\u00f6re \u201cRPA\u201d adl\u0131 bir protein, kromozomlar\u0131n u\u00e7 k\u0131sm\u0131ndaki telomerleri koruyarak genetik istikrar\u0131 sa\u011fl\u0131yor. Bu proteindeki bozukluklar, telomerlerin k\u0131salmas\u0131na yol a\u00e7arak aplastik anemi, miyelodisplastik sendrom ve akut miyeloid l\u00f6semi gibi ciddi hastal\u0131klara neden olabiliyor.
Telomerler, […]<\/p>\n","protected":false},"author":1,"featured_media":31249,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"footnotes":""},"categories":[2],"tags":[],"class_list":["post-31248","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"yoast_head":"\n
\u00d6l\u00fcmc\u00fcl hastal\u0131klar\u0131n gizemi \u00e7\u00f6z\u00fcld\u00fc - Haber Kuzey<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/haberkuzey.com\/index.php\/2025\/11\/03\/olumcul-hastaliklarin-gizemi-cozuldu\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00d6l\u00fcmc\u00fcl hastal\u0131klar\u0131n gizemi \u00e7\u00f6z\u00fcld\u00fc - Haber Kuzey\" \/>\n<meta property=\"og:description\" content=\"
ABD\u2019deki Wisconsin-Madison \u00dcniversitesi\u2019nden bilim insanlar\u0131, uzun s\u00fcredir nedeni bilinmeyen \u00f6l\u00fcmc\u00fcl hastal\u0131klar\u0131n ard\u0131ndaki biyolojik mekanizmay\u0131 \u00e7\u00f6zd\u00fc. Science dergisinde yay\u0131mlanan ara\u015ft\u0131rmaya g\u00f6re \u201cRPA\u201d adl\u0131 bir protein, kromozomlar\u0131n u\u00e7 k\u0131sm\u0131ndaki telomerleri koruyarak genetik istikrar\u0131 sa\u011fl\u0131yor. Bu proteindeki bozukluklar, telomerlerin k\u0131salmas\u0131na yol a\u00e7arak aplastik anemi, miyelodisplastik sendrom ve akut miyeloid l\u00f6semi gibi ciddi hastal\u0131klara neden olabiliyor.
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Haber Kuzey","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/03\/olumcul-hastaliklarin-gizemi-cozuldu\/","og_locale":"tr_TR","og_type":"article","og_title":"\u00d6l\u00fcmc\u00fcl hastal\u0131klar\u0131n gizemi \u00e7\u00f6z\u00fcld\u00fc - Haber Kuzey","og_description":"
ABD\u2019deki Wisconsin-Madison \u00dcniversitesi\u2019nden bilim insanlar\u0131, uzun s\u00fcredir nedeni bilinmeyen \u00f6l\u00fcmc\u00fcl hastal\u0131klar\u0131n ard\u0131ndaki biyolojik mekanizmay\u0131 \u00e7\u00f6zd\u00fc. Science dergisinde yay\u0131mlanan ara\u015ft\u0131rmaya g\u00f6re \u201cRPA\u201d adl\u0131 bir protein, kromozomlar\u0131n u\u00e7 k\u0131sm\u0131ndaki telomerleri koruyarak genetik istikrar\u0131 sa\u011fl\u0131yor. Bu proteindeki bozukluklar, telomerlerin k\u0131salmas\u0131na yol a\u00e7arak aplastik anemi, miyelodisplastik sendrom ve akut miyeloid l\u00f6semi gibi ciddi hastal\u0131klara neden olabiliyor.
Telomerler, […]","og_url":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/03\/olumcul-hastaliklarin-gizemi-cozuldu\/","og_site_name":"Haber Kuzey","article_published_time":"2025-11-03T05:49:35+00:00","og_image":[{"url":"https:\/\/trthaberstatic.cdn.wp.trt.com.tr\/resimler\/2412000\/dna-2413646.jpg","type":"","width":"","height":""}],"author":"haberkuzey","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"haberkuzey","Tahmini okuma s\u00fcresi":"2 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/03\/olumcul-hastaliklarin-gizemi-cozuldu\/#article","isPartOf":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/03\/olumcul-hastaliklarin-gizemi-cozuldu\/"},"author":{"name":"haberkuzey","@id":"https:\/\/haberkuzey.com\/#\/schema\/person\/3372109ec735f9333f4fa47ebb9605ca"},"headline":"\u00d6l\u00fcmc\u00fcl hastal\u0131klar\u0131n gizemi \u00e7\u00f6z\u00fcld\u00fc","datePublished":"2025-11-03T05:49:35+00:00","mainEntityOfPage":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/03\/olumcul-hastaliklarin-gizemi-cozuldu\/"},"wordCount":312,"commentCount":0,"image":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/03\/olumcul-hastaliklarin-gizemi-cozuldu\/#primaryimage"},"thumbnailUrl":"https:\/\/haberkuzey.com\/wp-content\/uploads\/2025\/11\/dna-2413646.jpg","articleSection":["D\u00fcnya"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/haberkuzey.com\/index.php\/2025\/11\/03\/olumcul-hastaliklarin-gizemi-cozuldu\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/03\/olumcul-hastaliklarin-gizemi-cozuldu\/","url":"https:\/\/haberkuzey.com\/index.php\/2025\/11\/03\/olumcul-hastaliklarin-gizemi-cozuldu\/","name":"\u00d6l\u00fcmc\u00fcl hastal\u0131klar\u0131n gizemi \u00e7\u00f6z\u00fcld\u00fc - 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