\n
\n\tKay\u0131p di\u015flerin tamamen yeniden \u00e7\u0131kmas\u0131, di\u015f hekimli\u011finde uzun s\u00fcredir hedeflenen bir hayal. Bug\u00fcne kadar implant ve protez gibi yapay \u00e7\u00f6z\u00fcmler, i\u015flevi k\u0131smen yerine getirse de do\u011fal di\u015fin biyolojik b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fc ve hissini tam olarak sa\u011flayam\u0131yor.<\/p>\n
\n\tBilim insanlar\u0131 bu nedenle, do\u011fal di\u015f olu\u015fumunun h\u00fccresel d\u00fczeyde nas\u0131l ger\u00e7ekle\u015fti\u011fini anlamaya \u00e7al\u0131\u015f\u0131yor.<\/p>\n
\n\tDi\u015f ve \u00e7evresindeki kemik olu\u015fumu olduk\u00e7a karma\u015f\u0131k bir s\u00fcre\u00e7. Mine, di\u015f \u00f6z\u00fc (pulpa) ve \u00e7ene kemi\u011fi h\u00fccreleri aras\u0131ndaki hassas ileti\u015fim a\u011flar\u0131, di\u015fin ta\u00e7, k\u00f6k ve destek dokular\u0131n\u0131 olu\u015fturuyor. Bu sinyal a\u011flar\u0131n\u0131n ayr\u0131nt\u0131lar\u0131 ise bug\u00fcne kadar tam \u00e7\u00f6z\u00fclememi\u015fti.<\/p>\n
\n\tK\u00f6k h\u00fccrelerin izini s\u00fcrd\u00fcler<\/h2>\n
\n\tBu bilgi eksikli\u011fini gidermek i\u00e7in Do\u00e7. Dr. Mizuki Nagata (Tokyo Bilim Enstit\u00fcs\u00fc) ve Dr. Wanida Ono (Teksas Sa\u011fl\u0131k Bilimleri Merkezi, Houston), Michigan \u00dcniversitesi\u2019nden bilim insanlar\u0131yla i\u015f birli\u011fi yapt\u0131.<\/p>\n
\n\tGenetik olarak de\u011fi\u015ftirilmi\u015f fareler \u00fczerinde yap\u0131lan \u00e7al\u0131\u015fmada, k\u00f6k h\u00fccrelerin di\u015f geli\u015fimi s\u0131ras\u0131nda hangi sinyallerle farkl\u0131la\u015ft\u0131\u011f\u0131 incelendi. Bulgular, Nature Communications dergisinin 2025 Temmuz say\u0131s\u0131nda iki ayr\u0131 makale olarak yay\u0131mland\u0131.<\/p>\n
\n\tAra\u015ft\u0131rmac\u0131lar, daha \u00f6nce tan\u0131mlanmam\u0131\u015f bir mezenkimal k\u00f6k h\u00fccre grubunun iki farkl\u0131 h\u00fccre hatt\u0131na ayr\u0131ld\u0131\u011f\u0131n\u0131 belirledi:<\/p>\n
\n\t\u0130lk grup, di\u015f k\u00f6k\u00fcn\u00fcn ucundaki apikal papilla ad\u0131 verilen yumu\u015fak dokuda yer al\u0131yor. Bu h\u00fccreler, kemik ili\u011finde de rol oynayan CXCL12 proteinini \u00fcretiyor. Wnt adl\u0131 sinyal yoluyla aktive olduklar\u0131nda, dentin (di\u015fin ana maddesi) olu\u015fturan odontoblastlara, sement \u00fcreten sementoblastlara ve hatta yeni kemik dokusu \u00fcreten osteoblastlara d\u00f6n\u00fc\u015febiliyor.<\/p>\n
\n\t\u0130kinci grup, geli\u015fmekte olan di\u015fi \u00e7evreleyen dental folik\u00fcl i\u00e7inde bulunuyor. Buradaki h\u00fccreler PTHrP proteini ta\u015f\u0131yor ve belirli ko\u015fullar alt\u0131nda di\u015f ba\u011f dokusunu, sementi ve alveolar kemi\u011fi olu\u015fturabiliyor. Ancak bu d\u00f6n\u00fc\u015f\u00fcm, yaln\u0131zca Hedgehog\u2013Foxf adl\u0131 bir sinyal yolunun bask\u0131land\u0131\u011f\u0131 durumlarda ger\u00e7ekle\u015fiyor. Dr. Nagata, \u201cBu mekanizma, di\u015f dokular\u0131na \u00f6zg\u00fc, kontroll\u00fc bir sinyal a\u00e7ma-kapama sistemiyle kemik olu\u015fumunu d\u00fczenliyor.\u201d ifadelerini kulland\u0131.<\/p>\n
\n\tYenileyici di\u015f tedavilerine kap\u0131 aral\u0131yor<\/h2>\n
\n\tAra\u015ft\u0131rma, di\u015f k\u00f6k\u00fc ve \u00e7evresindeki kemi\u011fin nas\u0131l do\u011fal olarak \u015fekillendi\u011fini daha \u00f6nce g\u00f6r\u00fclmemi\u015f ayr\u0131nt\u0131larla ortaya koydu. Bu bulgular, gelecekte k\u00f6k h\u00fccre tabanl\u0131 di\u015f ve kemik yenileme tedavilerinin temelini olu\u015fturabilir.<\/p>\n
\n\tDr. Nagata, \u201c\u00c7al\u0131\u015fmam\u0131z, di\u015f k\u00f6k\u00fc olu\u015fumunu y\u00f6neten mekanizmay\u0131 ortaya koyarak, di\u015f \u00f6z\u00fc, di\u015f eti ve kemik dokular\u0131n\u0131n yeniden olu\u015fturulabilece\u011fi yenilik\u00e7i tedavilere bilimsel bir temel sa\u011fl\u0131yor.\u201d dedi.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"
Kay\u0131p di\u015flerin tamamen yeniden \u00e7\u0131kmas\u0131, di\u015f hekimli\u011finde uzun s\u00fcredir hedeflenen bir hayal. Bug\u00fcne kadar implant ve protez gibi yapay \u00e7\u00f6z\u00fcmler, i\u015flevi k\u0131smen yerine getirse de do\u011fal di\u015fin biyolojik b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fc ve hissini tam olarak sa\u011flayam\u0131yor.
Bilim insanlar\u0131 bu nedenle, do\u011fal di\u015f olu\u015fumunun h\u00fccresel d\u00fczeyde nas\u0131l ger\u00e7ekle\u015fti\u011fini anlamaya \u00e7al\u0131\u015f\u0131yor.
Di\u015f ve \u00e7evresindeki kemik olu\u015fumu […]<\/p>\n","protected":false},"author":1,"featured_media":29623,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"footnotes":""},"categories":[2],"tags":[],"class_list":["post-30076","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"yoast_head":"\n
Bilim insanlar\u0131, di\u015f ve kemi\u011fi yenileyebilen k\u00f6k h\u00fccreler ke\u015ffetti - Haber Kuzey<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/haberkuzey.com\/index.php\/2025\/10\/14\/bilim-insanlari-dis-ve-kemigi-yenileyebilen-kok-hucreler-kesfetti\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bilim insanlar\u0131, di\u015f ve kemi\u011fi yenileyebilen k\u00f6k h\u00fccreler ke\u015ffetti - Haber Kuzey\" \/>\n<meta property=\"og:description\" content=\"
Kay\u0131p di\u015flerin tamamen yeniden \u00e7\u0131kmas\u0131, di\u015f hekimli\u011finde uzun s\u00fcredir hedeflenen bir hayal. Bug\u00fcne kadar implant ve protez gibi yapay \u00e7\u00f6z\u00fcmler, i\u015flevi k\u0131smen yerine getirse de do\u011fal di\u015fin biyolojik b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fc ve hissini tam olarak sa\u011flayam\u0131yor.
Bilim insanlar\u0131 bu nedenle, do\u011fal di\u015f olu\u015fumunun h\u00fccresel d\u00fczeyde nas\u0131l ger\u00e7ekle\u015fti\u011fini anlamaya \u00e7al\u0131\u015f\u0131yor.
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Haber Kuzey","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/haberkuzey.com\/index.php\/2025\/10\/14\/bilim-insanlari-dis-ve-kemigi-yenileyebilen-kok-hucreler-kesfetti\/","og_locale":"tr_TR","og_type":"article","og_title":"Bilim insanlar\u0131, di\u015f ve kemi\u011fi yenileyebilen k\u00f6k h\u00fccreler ke\u015ffetti - Haber Kuzey","og_description":"
Kay\u0131p di\u015flerin tamamen yeniden \u00e7\u0131kmas\u0131, di\u015f hekimli\u011finde uzun s\u00fcredir hedeflenen bir hayal. Bug\u00fcne kadar implant ve protez gibi yapay \u00e7\u00f6z\u00fcmler, i\u015flevi k\u0131smen yerine getirse de do\u011fal di\u015fin biyolojik b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fc ve hissini tam olarak sa\u011flayam\u0131yor.
Bilim insanlar\u0131 bu nedenle, do\u011fal di\u015f olu\u015fumunun h\u00fccresel d\u00fczeyde nas\u0131l ger\u00e7ekle\u015fti\u011fini anlamaya \u00e7al\u0131\u015f\u0131yor.
Di\u015f ve \u00e7evresindeki kemik olu\u015fumu […]","og_url":"https:\/\/haberkuzey.com\/index.php\/2025\/10\/14\/bilim-insanlari-dis-ve-kemigi-yenileyebilen-kok-hucreler-kesfetti\/","og_site_name":"Haber Kuzey","article_published_time":"2025-10-14T11:48:28+00:00","og_image":[{"url":"https:\/\/trthaberstatic.cdn.wp.trt.com.tr\/resimler\/1812000\/agiz-bakimi-a-1813433.jpg","type":"","width":"","height":""}],"author":"haberkuzey","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"haberkuzey","Tahmini okuma s\u00fcresi":"2 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/haberkuzey.com\/index.php\/2025\/10\/14\/bilim-insanlari-dis-ve-kemigi-yenileyebilen-kok-hucreler-kesfetti\/#article","isPartOf":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/10\/14\/bilim-insanlari-dis-ve-kemigi-yenileyebilen-kok-hucreler-kesfetti\/"},"author":{"name":"haberkuzey","@id":"https:\/\/haberkuzey.com\/#\/schema\/person\/3372109ec735f9333f4fa47ebb9605ca"},"headline":"Bilim insanlar\u0131, di\u015f ve kemi\u011fi yenileyebilen k\u00f6k h\u00fccreler ke\u015ffetti","datePublished":"2025-10-14T11:48:28+00:00","mainEntityOfPage":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/10\/14\/bilim-insanlari-dis-ve-kemigi-yenileyebilen-kok-hucreler-kesfetti\/"},"wordCount":474,"commentCount":0,"image":{"@id":"https:\/\/haberkuzey.com\/index.php\/2025\/10\/14\/bilim-insanlari-dis-ve-kemigi-yenileyebilen-kok-hucreler-kesfetti\/#primaryimage"},"thumbnailUrl":"https:\/\/haberkuzey.com\/wp-content\/uploads\/2025\/09\/agiz-bakimi-a-1813433.jpg","articleSection":["D\u00fcnya"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/haberkuzey.com\/index.php\/2025\/10\/14\/bilim-insanlari-dis-ve-kemigi-yenileyebilen-kok-hucreler-kesfetti\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/haberkuzey.com\/index.php\/2025\/10\/14\/bilim-insanlari-dis-ve-kemigi-yenileyebilen-kok-hucreler-kesfetti\/","url":"https:\/\/haberkuzey.com\/index.php\/2025\/10\/14\/bilim-insanlari-dis-ve-kemigi-yenileyebilen-kok-hucreler-kesfetti\/","name":"Bilim insanlar\u0131, di\u015f ve kemi\u011fi yenileyebilen k\u00f6k h\u00fccreler ke\u015ffetti - 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